Bridging Molecules, Discovery and Innovation
“We believe in redefining chemical research with a focus on discovery, sustainability, and practical solutions to modern challenges in health and the environment.”
Protein Chemistry
We study the fundamental principles in protein folding/misfolding in neurodegenerative diseases. We also determined the interaction of Clr4 methyltransferase with H3K9 nucleosomes and combined the cryo-EM density maps with solution NMR spectroscopy to solve the structure at atomic resolution. read more
Drug Discovery
We are actively engaged in fragment-based drug discovery (FBDD) to identify and optimize small molecule fragments that bind to biological targets. By leveraging advanced biophysical techniques such as NMR spectroscopy, cryoEM, and computational docking, we screen and analyze these fragments for their potential therapeutic compounds. read more
Emerging Contaminants
Emerging contaminants gathered worldwide attention due to their potential impacts on both food sciences and maritime environments. These contaminants enter the supply chain through agricultural practices, water sources, or packaging materials, and pose potential risks to human health and food safety. read more
Methodology
The alignment of molecules with the magnetic field induces residual dipolar couplings (RDCs), paramagnetic relaxation enhancements (PREs) and pseudo-contact shifts (PCSs). We have developed a method for the structural determination of small molecules via an internal alignment medium through paramagnetic lanthanide tags.read more
A passionate team of researchers dedicated to advancing drug discovery and addressing emerging contaminants.
We employ spectroscopic and biophysical-chemical methods to explore the fundamental principles of protein folding/misfolding and shed lights on the structural integrities and thermodynamic conformational modifications of complex chemical and biochemical processes at atomic resolution. We also incorporate both retrospective analysis and real time data collection on small organic molecules to elucidate thermodynamic and kinetic contributions in identifying molecules that possess suitable candidacy for conventional drugs or potential existence as emerging contaminants.
We are limited only by our imagination in the molecules we can create. Chemistry is the art of turning dreams into reality”
Jean-Marie Lehn, Nobel Laureate in Chemistry, 1987
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“Our research group invites you to partner with us as we innovate and collaborate to advancing science.”
BioPhysical Chemistry Research Group 